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US 11,630,052 B2Granted
Ultra-high throughput detection of fluorescent droplets using time domain encoded optofluidics
AssigneeThe Trustees of the University of Pennsylvania
InventorsDavid A Issadore, Venkata Yelleswarapu
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Abstract
A high-throughput optofluidic device for detecting fluorescent droplets is disclosed. The device uses time-domain encoded optofluidics to detect a high rate of droplets passing through parallel microfluidic channels. A light source modulated with a minimally correlating maximum length sequences is used to illuminate the droplets as they pass through the microfluidic device. By correlating the resulting signal with the expected pattern, each pattern formed by passing droplets can be resolved to identify individual droplets.
Claims11
A device comprising:
- a light source configured to illuminate a plurality of droplets passing through a microfluidic channel;
- a controller configured to flash the light source in a time-domain modulated sequence;
- and
- a photo sensor configured to capture an image of the microfluidic channel,
- wherein the time-domain modulated sequence has a duration, d, wherein the image has an exposure time, t, and wherein t is greater than or equal to d.
2 more elements
Dependencies are inferred from the claim text.