Blood biomarkers for respiratory infections
AssigneeThe George Washington University a Congressionally Chartered Not-for-Profit Corporation
InventorsTimothy A. Mccaffrey, Lakhmir S. Chawla
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Abstract
Methods and kits for diagnosing and/or treating a lower respiratory infection in a subject include obtaining a biological sample from the subject; detecting RNA expression levels of one or more biomarkers in the biological sample and comparing the expression levels of the one or more three biomarkers to at least one invariant control marker wherein an increase or decrease in the level of expression of the one or more biomarkers as compared to the at least one invariant control marker is indicative of a lower respiratory infection.
Claims10
A method comprising administering a treatment for a lower respiratory infection to a subject, wherein a nucleic acid sample from the subject has been assayed to detect the expression level of at least the biomarkers of alkaline phosphatase liver isoform (ALPL), interleukin-8 receptor beta (IL8RB), and defensin-alpha 1, and the subject was determined to have an at least three-fold increase or decrease in the expression level of the biomarkers as compared to at least one invariant control marker, wherein the at least three-fold increase or decrease in the expression level of the biomarkers is indicative of a lower respiratory infection, wherein the treatment for the lower respiratory infection comprises antibiotics, antivirals, anti-inflammatories, or any combination thereof.
Dependencies are inferred from the claim text.