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US 11,629,360 B2Granted
Method for production of modified cells expressing HOX and modified cells obtained by the method
OwnerMassimo Dominici, Olivia Candiniinventors
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Abstract
A cell modified for obtaining increased proliferative capacity, decreased aging and enhanced regenerative capacity, its modification involving HOXB7 overexpression obtained using a gene vector that can insert the coding sequence into the cell, thereby affording increased protein production.
Claims6
A method of obtaining over-expression of a HOXB7 protein encoded by a nucleotide sequence having SEQ ID NO 2 within mesenchymal stem cells (MSCs) to form skeletal tissue, comprising:
- yielding retroviral particles carrying a coding sequence for said HOXB7 protein;
- and
- genetically modifying said MSCs by infecting said MSCs with said retroviral particles to produce modified cells having a faster expansion, a lower senescence rate, and an increased ability to form said skeletal tissue than the MSCs before infecting
- wherein said MSCs comprise isolated MSCs of human origin chosen from bone marrow, fat, umbilical cord, menstrual liquids, amniotic liquid, synovial liquid, tooth pulp, hepatic tissue, pulmonary tissue, or pancreatic tissue.
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Dependencies are inferred from the claim text.