Linkage modified oligomeric compounds and uses thereof

An oligomeric compound comprising a modified oligonucleotide consisting of 12-22 linked nucleosides, wherein the modified oligonucleotide has a 5′-region, a central region, and a 3′-region, wherein:

• the 5′-region consists of 1-6 linked nucleosides, each comprising a modified sugar moiety;
• the 3′-region consists of 1-6 linked nucleosides, each comprising a modified sugar moiety;
• the central region is a deoxy region;
• and
• the central region consists of 7-12 linked nucleosides and has the formula (from 5′ to 3′):
• (Nd1)L1(Nd2)L2(Nd3)L3(Nd4)L4[(Nd)L5]q, wherein:
• Nd1, Nd2, Nd3, Nd4 are independently selected from a stereo-standard DNA nucleoside and a 2′-substituted nucleoside;
• with the proviso that no more than one of Nd1, Nd2, Nd3, or Nd4 is a 2′-substituted nucleoside;
• q is from 3-8;
• each of L1, L2, L3, L4, and each L5 is an internucleoside linkage:
• two, three, or four of L1, L2, L3, and L4 are mesyl phosphoramidate internucleoside linkages;
• and
• each L5 is a phosphorothioate internucleoside linkage.