US 11,629,235 B2Granted

Urea-functionalized sol-gel

AssigneeKing Fahd University of Petroleum and Minerals

InventorsKhalid R. Alhooshani, Shehzada Muhammad Sajid Jilani

Life of this patent

Estimating the term…

Loading patent…

Abstract

Urea and amine comprising sol-gel hybrid coatings have been developed for numerous applications, including capillary microextraction-high performance liquid chromatographic analysis from aqueous samples. A fused silica capillary may be coated from the inside with surface bonded coating material and may be created by in-situ sol-gel reaction(s). Urea-functionalized coatings can be immobilized on the inner surface of a capillary by condensing silanol groups of capillary and sol-solution. Urea functionalized, sol-gel coated capillaries may be installed, e.g., in HPLC manual injection ports, and optionally pre-concentrated analytes including phenols, ketones, aldehydes, and/or polyaromatic hydrocarbons, from highly polar to non-polar, maybe analyzed by online extraction and high-performance liquid chromatographic. Such coatings may achieve sensitivities with lower detection limits (S/N=3) of 0.10 ng/mL to 14.29 ng/mL, with reproducibilities of <12.0% RSD (n=3), or <10.0% RSD (n=3) by exchanging the capillary of the same size.

Claims17

Dependent claims

A glass capillary-, comprising an inner surface and an outer surface,

wherein the inner surface comprises a coating comprising a sol-gel component HA comprising reacted units of:
a sol-gel precursor having a structure (I)
R′O3Si—(R′2C)a—HN—C(═X)—NH—(CR′2)b—Si(OR′);
(I),
wherein X is 0 or S, R′ is independently H, methyl, ethyl, propyl, s-propyl, butyl, s-butyl, isobutyl, t-butyl, pentyl, s-pentyl, isoamyl, neopentyi, C6-alkyl, phenyl, or pyridyl, and a and b are independently in a range of from 1 to 20;
and
a sol-gel active polymer having a structure (ii)
[HO—(HRC)m—]2-y—HyN—(CHR)n—[—(SiR2—O)x—]—SiR2—(CHR)p—NHz—[(CHR)q—OH]2-z (II),
wherein R is independently H, methyl, ethyl, propyl, s-propyl, butyl, s-butyl, isobutyl, t-butyl, pentyl, s-pentyl, isoamyl, neopentyl, C6-alkyl, phenyl, or pyridyl, y and z are independently 0 or 1, x is in a range of from 5 to 2,500, and m, n, p, and q are independently in a range of from 1 to 20,
wherein the coating has a thickness in a range of from 1 to 10 microns, and
wherein the sol-gel component is covalently bonded to the inner surface of the glass capillary.

8 more elements

Dependencies are inferred from the claim text.