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US 11,629,200 B2Granted
Means and methods for counteracting myeloproliferative or lymphoproliferative disorders
AssigneeKling Biotherapeutics B.V.
InventorsHergen Spits, Tim Beaumont, Marijn Aletta Gillissen, Adrianus Quirinus Bakker, Mette Deborah Hazenberg, Martijn Kedde
Life of this patent
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Abstract
The invention provides human AML-specific binding compounds that are able to bind a cell surface component of AML cells. Therapeutic uses of binding compounds against AML are also provided.
Claims16
A synthetic or recombinant nucleic acid molecule or functional equivalent thereof, comprising:
- a sequence encoding the heavy chain CDR1 sequence of SEQ ID NO:
- 209, and
- a sequence encoding the heavy chain CDR2 sequence of SEQ ID NO:
- 213, and
- a sequence encoding the heavy chain CDR3 sequence of SEQ ID NO:
- 217, and
- a sequence encoding the light chain CDR1 sequence of SEQ ID NO:
- 221, and
- a sequence encoding the light chain CDR2 sequence of SEQ ID NO:
- 225, and
- a sequence encoding the light chain CDR3 sequence of SEQ ID NO:
- 229.
9 more elements
A vector comprising:
- a nucleic acid sequence or functional equivalent thereof encoding the heavy chain CDR1 sequence of SEQ ID NO:
- 209, and
- a nucleic acid sequence or functional equivalent thereof encoding the heavy chain CDR2 sequence of SEQ ID NO:
- 213, and
- a nucleic acid sequence or functional equivalent thereof encoding the heavy chain CDR3 sequence of SEQ ID NO:
- 217, and
- a nucleic acid sequence or functional equivalent thereof encoding the light chain CDR1 sequence of SEQ ID NO:
- 221, and
- a nucleic acid sequence or functional equivalent thereof encoding the light chain CDR2 sequence of SEQ ID NO:
- 225, and
- a nucleic acid sequence or functional equivalent thereof encoding the light chain CDR3 sequence of SEQ ID NO:
- 229.
9 more elements
A composition comprising one or more nucleic acid molecules or functional equivalents thereof, comprising:
- a sequence encoding the heavy chain CDR1 sequence of SEQ ID NO:
- 209, and
- a sequence encoding the heavy chain CDR2 sequence of SEQ ID NO:
- 213, and
- a sequence encoding the heavy chain CDR3 sequence of SEQ ID NO:
- 217, and
- a sequence encoding the light chain CDR1 sequence of SEQ ID NO:
- 221, and
- a sequence encoding the light chain CDR2 sequence of SEQ ID NO:
- 225, and
- a sequence encoding the light chain CDR3 sequence of SEQ ID NO:
- 229.
9 more elements
A host cell comprising one or more nucleic acid molecules or functional equivalents thereof, comprising:
- a sequence encoding the heavy chain CDR1 sequence of SEQ ID NO:
- 209, and
- a sequence encoding the heavy chain CDR2 sequence of SEQ ID NO:
- 213, and
- a sequence encoding the heavy chain CDR3 sequence of SEQ ID NO:
- 217, and
- a sequence encoding the light chain CDR1 sequence of SEQ ID NO:
- 221, and
- a sequence encoding the light chain CDR2 sequence of SEQ ID NO:
- 225, and
- a sequence encoding the light chain CDR3 sequence of SEQ ID NO:
- 229.
9 more elements
Dependencies are inferred from the claim text.