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US 11,629,198 B2Granted
Fusion proteins and antibodies targeting human red blood cell antigens
AssigneeThe Trustees of the University of Pennsylvania
InventorsCarlos H. Villa, Vladimir R. Muzykantov, Donald L. Siegel, Colin Greineder
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Abstract
Compositions and methods are provided for loading cargoes onto red blood cells. Provided herein are novel antibodies, fragments, fusion proteins and other conjugates which specifically bind red blood cells via RHCE or Band 3.
Claims26
An antibody or fragment thereof which specifically binds an epitope on an erythrocyte, said antibody or fragment thereof comprising:
- a) a heavy chain variable domain comprising a CDR1 comprising SEQ ID NO:
- 1, a CDR2 comprising SEQ ID NO:
- 2, and a CDR3 comprising SEQ ID NO:
- 3 and light chain variable domain comprising a CDR1 comprising SEQ ID NO:
- 4, a CDR2 comprising SEQ ID NO:
- 5, and a CDR3 comprising SEQ ID NO:
- 6;
- b) a heavy chain variable domain comprising a CDR1 comprising SEQ ID NO:
- 7, a CDR2 comprising SEQ ID NO:
- 8, and a CDR3 comprising SEQ ID NO:
- 9 and light chain variable domain comprising a CDR1 comprising SEQ ID NO:
- 10, a CDR2 comprising SEQ ID NO:
- 11, and a CDR3 comprising SEQ ID NO:
- 12;
- or
- c) a heavy chain variable domain comprising a CDR1 comprising SEQ ID NO:
- 13, a CDR2 comprising SEQ ID NO:
- 14, and a CDR3 comprising SEQ ID NO:
- 15 and light chain variable domain comprising a CDR1 comprising SEQ ID NO:
- 16, a CDR2 comprising SEQ ID NO:
- 17, and a CDR3 comprising SEQ ID NO:
- 18.
19 more elements
Dependencies are inferred from the claim text.