EGFR binding molecules
AssigneeF-star Therapeutics Limited
InventorsMihriban Tuna, Kin-Mei Leung, Haijun Sun, Melanie Medcalf, Samine Isaac
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Abstract
The application relates to specific binding members which bind the human epidermal growth factor receptor (EGFR). The specific binding members preferably comprise an EGFR antigen-binding site which may be located in two or more structural loops of a CH3 domain of the specific binding member. The specific binding members are expected to find application in the treatment of cancers expressing EGFR.
Claims20
An antibody molecule, comprising an EGFR antigen-binding site located in a CH3 domain of the antibody molecule, wherein the EGFR binding site comprises the amino acid sequences:
- (i)
- (SEQ ID NO:
- 1)
- LDEGGP
- and
- (SEQ ID NO:
- 3)
- SHWRWYS;
- (ii)
- (SEQ ID NO:
- 1)
- LDEGGP
- and
- (SEQ ID NO:
- 8)
- SYWRWVK;
- or
- (iii)
- (SEQ ID NO:
- 13)
- TDDGP
- and
- (SEQ ID NO:
- 14)
- SYWRWYK;
- and wherein the amino acid sequence set forth in SEQ ID NO:
- 1 or 13 is located in the AB loop of the CH3 domain and the amino acid sequence set forth in SEQ ID NO:
- 3, 8, or 14 is located in the EF loop of the CH3 domain.
Dependencies are inferred from the claim text.