Canine antibody therapeutic for treating cancer
AssigneeOregon State University
InventorsDan Vincent Mourich, Carl E. Ruby, Shay Bracha, Christopher Keith Cebra
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Abstract
Disclosed are isolated single heavy chain variable (VHH) monoclonal antibodies, antigen binding fragments thereof, and bispecific antibodies include these VHH monoclonal antibodies, wherein the VHH monoclonal antibody or antigen binding fragment specifically binds a canine programmed death (PD)-1. Nucleic acid molecules encoding these VHH monoclonal antibodies and antigen binding fragments are also disclosed, as are expression vectors including these nucleic acid molecules and host cells including these expression vectors. Methods of detecting canine PD-1, and methods of increasing cytotoxic T cell activity and treating tumors are also disclosed.
Claims20
An isolated single heavy chain variable domain (VHH) monoclonal antibody, or an antigen binding fragment thereof, comprising a VHH domain, wherein the VHH domain comprises a complementarity determining region (CDR)1, a CDR2 and a CDR3, and wherein the VHH monoclonal antibody or antigen binding fragment specifically binds a canine programmed death (PD)-1, and wherein
- a) the CDR1 comprises the amino acid sequence of SEQ ID NO:
- 2, the CDR2 comprises the amino acid sequence of SEQ ID NO:
- 3, and the CDR3 comprises amino the amino acid sequence of SEQ ID NO:
- 4;
- b) the CDR1 comprises the amino acid sequence of SEQ ID NO:
- 6, the CDR2 comprises the amino acid sequence of SEQ ID NO:
- 7, and the CDR3 comprises amino the amino acid sequence of SEQ ID NO:
- 8;
- c) the CDR1 comprises the amino acid sequence of SEQ ID NO:
- 10, the CDR2 comprises the amino acid sequence of SEQ ID NO:
- 11, and the CDR3 comprises amino the amino acid sequence of SEQ ID NO:
- 12;
- d) the CDR1 comprises the amino acid sequence of SEQ ID NO:
- 14, the CDR2 comprises the amino acid sequence of SEQ ID NO:
- 15, and the CDR3 comprises amino the amino acid sequence of SEQ ID NO:
- 16;
- or
- e) the CDR1 comprises the amino acid sequence of SEQ ID NO:
- 18, the CDR2 comprises the amino acid sequence of SEQ ID NO:
- 19, and the CDR3 comprises amino the amino acid sequence of SEQ ID NO:
- 20.
Dependencies are inferred from the claim text.