Chimeric and humanized anti-human CTLA4 monoclonal antibodies and uses thereof

A method of treating lung cancer in a subject in need thereof, comprising administering a composition comprising an anti-CTLA4 antibody or an antigen binding fragment thereof to the subject, wherein the anti-CTLA4 antibody or the antigen binding fragment is capable of binding to a human CTLA4 protein and comprises:

• (a) a light chain variable region comprising:
• (i) a complementarity determining region (CDR) 1 comprising the amino acid sequence set forth in SEQ ID NO:
• 21;
• (ii) a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:
• 36, 37 or 38;
• and, (iii) a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:
• 23;
• and,
• (b) a heavy chain variable region comprising:
• (i) a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:
• 24;
• (ii) a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:
• 33, 34 or 35;
• and, (iii) a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:
• 26.