Anti-transthyretin antibodies
AssigneesNovo Nordisk A/S, University Health Network
InventorsTarlochan S. Nijjar, Avijit Chakrabartty, Jeffrey N. Higaki
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Abstract
The invention provides antibodies that specifically bind to transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases or disorders associated with TTR accumulation or accumulation of TTR deposits (e.g., TTR amyloidosis). The antibodies can also be used for diagnosing TTR amyloidosis and inhibiting or reducing aggregation of TTR, among other applications.
Claims18
An antibody specifically binding human transthyretin, comprising a heavy chain and a light chain, wherein the heavy chain comprises a mature heavy chain variable region having the amino acid sequence of SEQ ID NO:9, and wherein the light chain comprises a mature light chain variable region having the amino acid sequence of SEQ ID NO:17.
Dependencies are inferred from the claim text.