Compositions and methods for the removal of biofilms
AssigneeResearch Institute of Nationwide Children's Hospital
InventorsSteven D. Goodman, Lauren O. Bakaletz
Life of this patent
Estimating the term…
Abstract
This disclosure provides isolated or recombinant polypeptides that are useful to vaccinate individuals suffering from chronic/recurrent biofilm disease or as a therapeutic for those with an existing infection. The individual's immune system will then naturally generate antibodies which prevent or clear these bacteria from the host by interfering with the construction and or maintenance of a functional protective biofilm. Alternatively, antibodies to the polypeptides can be administered to treat or prevent infection. Bacteria that cannot form functional biofilms are more readily cleared by the remainder of the host's immune system and/or traditional antibiotics.
Claims24
A method to prevent formation of or to dissolve a biofilm in a subject in need thereof, comprising administering to the subject an isolated polypeptide consisting of the amino acid sequence of RPGRNPKTGDVVPVSARRVV (SEQ ID NO:
- 352) or an equivalent thereof, wherein the equivalent consists of the amino acid sequence of SEQ ID NO:
- 352 and either or both of the following:
- (i) up to 20 random amino acids on the amine terminus of the amino acid sequence of SEQ ID NO:
- 352;
- or
- (ii) up to 15 random amino acids on the carboxy terminus of the amino acid sequence of SEQ ID NO:
- 352, and
- wherein the subject has chronic obstructive pulmonary disease (COPD), chronic cough, cystic fibrosis (CF), community acquired pneumonia (CAP), or a combination thereof.
Dependencies are inferred from the claim text.