RSV F protein compositions and methods for making same
AssigneeGlaxosmithkline Biologicals SA
InventorsKurt Swanson, Philip R. Dormitzer
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Abstract
The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.
Claims5
An immunogenic composition comprising a recombinant RSV F polypeptide of a RSV A subgroup and a recombinant RSV F polypeptide of a RSV B subgroup;
- wherein the recombinant RSV F polypeptide of the RSV A subgroup and the RSV F polypeptide of the RSV B subgroup comprise a trimerizing sequence from bacteriophage T4 fibritin;
- and
- wherein the recombinant RSV F polypeptide of the RSV A subgroup and the RSV F polypeptide of the RSV B subgroup do not comprise a transmembrane region or cytoplasmic tail.
Dependencies are inferred from the claim text.