Bifunctional angiogenesis inhibitor and use thereof
AssigneeRemegen Co., Ltd.
InventorsJing Jiang, Jianmin Fang, Xuejing Luan, Xuejing Yao, Ling Wang
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Abstract
The present invention relates to a bifunctional angiogenesis inhibitor, which has VEGF inhibitory activity and FGF inhibitory activity, and can inhibit VEGF and FGF dual factors-induced or high glucose-induced cell proliferation, cell migration, and/or lumen formation. The present invention also relates to the use of the bifunctional angiogenesis inhibitor in inhibiting retinal angiogenesis, such as diabetic retinopathy, age-related macular degeneration and the like.
Claims21
A bifunctional angiogenesis inhibitor having the amino acid sequence shown in SEQ ID NO:
- 1.
An isolated polynucleotide comprising a nucleotide sequence encoding a bifunctional angiogenesis inhibitor, wherein the amino acid sequence of the bifunctional angiogenesis inhibitor is shown in SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.