Use of peptides as therapeutic agent for autoimmune diseases and bone diseases
AssigneeKine Sciences Co., Ltd.
InventorsDae Ho Cho, Kyung Eun Kim, Myun Soo Kim, Sun Young Park, Hee Young Jung
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Abstract
The present invention relates to use of peptides as a therapeutic agent, wherein it has been confirmed that the peptides of the present invention significantly inhibit the activity of T cells and the differentiation of T helper 17 cells (Th17 cells), which are associated with autoimmune disease, and have remarkable effects of treating and improving arthritis in an animal model of arthritis. Therefore, the peptides may be used as an active ingredient in therapeutic agents for various autoimmune diseases such as bone disease, inflammatory disease or rheumatoid arthritis.
Claims6
A synthetic peptide consisting of an amino acid sequence of Formula 1 below:
- (X1—X2—X3)n [Formula 1]
- wherein, X1 and X2 are serine (S), to X3 is proline (P),
- n is an integer from 2 to 10,
- when n is 2, the amino acid sequence of Formula 1 is represented by SEQ ID NO:
- 96,
- when n is 3, the amino acid sequence of Formula 1 is represented by SEQ ID NO:
- 97,
- when n is 4, the amino acid sequence of Formula 1 is represented by SEQ ID NO:
- 98,
- when n is 5, the amino acid sequence of Formula 1 is represented by SEQ ID NO:
- 99,
- when n is 6, the amino acid sequence of Formula 1 is represented by SEQ ID NO:
- 100,
- when n is 7, the amino acid sequence of Formula 1 is represented by SEQ ID NO:
- 101,
- when n is 8, the amino acid sequence of Formula 1 is represented by SEQ ID NO:
- 102,
- when n is 9, the amino acid sequence of Formula 1 is represented by SEQ ID NO:
- 103,
- when n is 10, the amino acid sequence of Formula 1 is represented by SEQ ID NO:
- 104.
A method for treating bone disease, inflammatory disease or autoimmune disease, comprising administering a synthetic peptide consisting of an amino acid sequence of Formula 1 below in a pharmaceutically effective dose to a subject with bone disease, inflammatory disease or autoimmune disease:
- (X1—X2—X3)n [Formula 1]
- wherein, X1 and X2 are serine (S), X3 is proline (P),
- n is an integer from 2 to 10,
- when n is 2, the amino acid sequence of Formula 1 is represented by SEQ ID NO:
- 96,
- when n is 3, the amino acid sequence of Formula 1 is represented by SEQ ID NO:
- 97,
- when n is 4, the amino acid sequence of Formula 1 is represented by SEQ ID NO:
- 98,
- when n is 5, the amino acid sequence of Formula 1 is represented by SEQ ID NO:
- 99,
- when n is 6, the amino acid sequence of Formula 1 is represented by SEQ ID NO:
- 100,
- when n is 7, the amino acid sequence of Formula 1 is represented by SEQ ID NO:
- 101,
- when n is 8, the amino acid sequence of Formula 1 is represented by SEQ ID NO:
- 102,
- when n is 9, the amino acid sequence of Formula 1 is represented by SEQ ID NO:
- 103,
- when n is 10, the amino acid sequence of Formula 1 is represented by SEQ ID NO:
- 104.
Dependencies are inferred from the claim text.