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US 11,629,163 B2Granted
Methods of synthesizing nicotinamide riboside
AssigneeElysium Health, Inc.
InventorsEric Marcotulli, Dan Alminana, Ryan Dellinger, Mark Morris, Rajesh Thamatam
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Abstract
Provided herein are efficient and scalable methods for the synthesis of nicotinamide riboside from riboside triacetate. Also provided are compositions comprising nicotinamide riboside, and therapeutic methods employing nicotinamide riboside.
Claims5
A method of synthesis comprising the steps of:
- (a) combining compound 1 and a chlorinating agent, thereby producing a first reaction mixture comprising compound 2, wherein:
- compound 1 is represented by
- compound 2 is represented by
- and the chlorinating agent is gaseous HCl or HCl in dioxane;
- and
- (b) combining compound 2 with nicotinamide and a trialkylamine, thereby producing a second reaction mixture comprising compound 3, wherein:
- compound 3 is represented by
4 more elements
Dependencies are inferred from the claim text.