US 11,629,161 B2Granted

Synthesis of 1:1:1 co-crystal of 1-cyano-2-(4-cyclopropyl-benzyl)-4-(ß-d-glucopyranos-1-yl)-benzene, L-proline and water

OwnerMatthias Eckhardt, Monika Brink +6inventors

InventorsMatthias Eckhardt, Monika Brink, Frank Himmelsbach, Stefan Sahli, Chutian Shu, Xiao-Jun Wang, Beat Theodor Weber, Bing-Shiou Yang

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Abstract

Intermediate compounds are described herein and which are used to manufacture a crystalline compound 1-cyano-2-(4-cyclopropyl-benzyl)-4-(β-D-glucopyranos-1-yl)-benzene L-proline monohydrate.

Claims2

Dependent claims

An intermediate compound selected from the group consisting of:

Dependencies are inferred from the claim text.

Facts

Application: 17/537,612Filed 30 Nov 2021 · division
Priority: EP 1720831519 Dec 2017
Published: US 2022/0081461 A117 Mar 2022
Granted: 18 Apr 2023
Term ends: Not estimatedThe source records don’t support an estimate.

Classification12 codes

C07D 309/10
With hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals,…:…
C07H 1/00
Processes for the preparation of sugar derivatives
C07C 69/614
Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety: of…
C07C 255/50
Having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton: to carbon atoms of non-condensed six-membered…

Family

PCT/EP2018/085193Parent of this division · filed 17 Dec 2018
US 2022/0081461 A1Pre-grant publication · published 17 Mar 2022
Application16/771,717Parent of this division
US 11,225,500 B2Parent of this division
US 2021/0139520 A1Published application
US 11,629,161 B2This patent

From the US filing history. Foreign family members aren’t listed.

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