Back to results
US 11,629,153 B2Granted
Forms and compositions of a MK2 inhibitor
AssigneeCelgene CAR LLC
InventorsJianxin Han, Lianfeng Huang, Uday Jain, Ying Li, John Malona, Kevin Molter, Chittari Pabba, Alexander L. Ruchelman, Jean Xu, Daozhong Zou
Life of this patent
Estimating the term…
Abstract
The present invention provides solid forms of an MK2 inhibitor, compositions thereof, and methods of using the same.
Claims33
A crystalline form of Compound 1:
- wherein Compound 1 is unsolvated;
- and
- the crystalline form is characterized by one or more peaks in its powder X-ray diffraction pattern selected from those at:
- i) about 6.19, about 9.33, about 9.64, about 12.39, about 12.49, about 12.59, about 13.11, about 13.25, about 16.31, about 18.70, about 18.84, about 19.09, about 20.92, about 21.35, about 23.17, about 24.02, about 24.94, about 26.44, about 29.14, and about 30.04 degrees 2-theta;
- or
- ii) about 6.19, about 7.04, about 9.30, about 9.58, about 9.64, about 12.54, about 18.69, about 19.33, about 21.34, about 27.52, and about 29.18 degrees 2-theta;
- or
- iii) about 4.89, about 6.01, about 6.10, about 9.83, about 12.06, about 20.55, about 20.98, about 25.75, and about 26.42 degrees 2-theta.
5 more elements
A crystalline form of Compound 1:
- wherein the crystalline form is a hydrate;
- and
- the crystalline form is characterized by one or more peaks in its powder X-ray diffraction pattern selected from those at:
- i) about 7.03, about 13.54, about 13.91, about 14.13, about 21.25, about 21.51, about 24.73, and about 25.77 degrees 2-theta;
- or
- ii) about 6.80, about 7.13, about 9.95, about 15.48, about 15.64, and about 21.44 degrees 2-theta.
3 more elements
A crystalline form of Compound 1:
- wherein the crystalline form is a solvate;
- and
- the crystalline form is characterized by one or more peaks in its powder X-ray diffraction pattern selected from those at:
- i) about 7.11, about 8.92, about 10.41, about 10.68, about 11.00, about 13.70, about 22.11, and about 23.73 degrees 2-theta;
- or
- ii) about 6.36, about 9.56, about 9.94, about 10.41, about 10.77, about 12.71, about 12.89, about 17.56, about 18.12, about 19.09, about 19.35, about 19.74, about 20.83, about 23.49, and about 24.08 degrees 2-theta;
- or
- iii) about 10.37, about 12.81, about 19.31, about 19.75, and about 24.06 degrees 2-theta;
- or
- iv) about 6.73, about 8.44, about 13.45, about 15.27, about 17.53, about 20.54, about 23.95, and about 24.49 degrees 2-theta.
7 more elements
The crystalline form according to embodiment 14, wherein the crystalline form is characterized by a powder X-ray diffraction pattern having peaks at about 10.37, about 12.81, about 19.31, about 19.75, and about 24.06 degrees 2-theta.
Dependencies are inferred from the claim text.