Compound with anticancer activity

A compound of the formula I or a pharmaceutically acceptable salt thereof:

• wherein, L1 and L2 are the same or different and each represents a group represented by a member selected from the group consisting of:
• wherein,
• at least one of L1 and L2 is a member selected from formula (A),
• the wavy line represents a bonding site to S,
• RA1, RA2, and RA3 are the same or different and each represents a hydrogen atom or lower alkyl,
• RA5 represents
• a hydrogen atom,
• a halogen,
• lower alkyl optionally substituted with one or more substituents selected from the group consisting of a halogen, hydroxy, methoxy, ethoxy, nitro, cyano, carboxy, methoxycarbonyl, ethoxycarbonyl, amino, methylamino, ethylamino, dimethylamino, diethylamino, carbamoyl, methylcarbamoyl, ethylcarbamoyl, dimethylcarbamoyl, diethylcarbamoyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, furyl, thiophenyl, pyrrolyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, triazolyl, oxadiazolyl, tetrazolyl, pyridyl, pyridazinyl, pyrimidinyl, and pyrazinyl,
• lower alkenyl optionally substituted with one or more substituents selected from the group consisting of a halogen, hydroxy, methoxy, ethoxy, nitro, cyano, carboxy, methoxycarbonyl, ethoxycarbonyl, amino, methylamino, ethylamino, dimethylamino, diethylamino, carbamoyl, methylcarbamoyl, ethylcarbamoyl, dimethylcarbamoyl, diethylcarbamoyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, furyl, thiophenyl, pyrrolyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, triazolyl, oxadiazolyl, tetrazolyl, pyridyl, pyridazinyl, pyrimidinyl, and pyrazinyl,
• tetrahydropyridinyl optionally substituted with one or more substituents selected from the group consisting of a halogen, methyl, ethyl, hydroxy, methoxy, ethoxy, nitro, cyano, carboxy, methoxycarbonyl, ethoxycarbonyl, amino, methylamino, ethylamino, dimethylamino, diethylamino, carbamoyl, methylcarbamoyl, ethylcarbamoyl, dimethylcarbamoyl, and diethylcarbamoyl,
• dihydro-1H-pyrrolyl optionally substituted with one or more substituents selected from the group consisting of a halogen, methyl, ethyl, hydroxy, methoxy, ethoxy, nitro, cyano, carboxy, methoxycarbonyl, ethoxycarbonyl, amino, methylamino, ethylamino, dimethylamino, diethylamino, carbamoyl, methylcarbamoyl, ethylcarbamoyl, dimethylcarbamoyl, and diethylcarbamoyl, or
• tetrahydro-1H-azepinyl optionally substituted with one or more substituents selected from the group consisting of a halogen, methyl, ethyl, hydroxy, methoxy, ethoxy, nitro, cyano, carboxy, methoxycarbonyl, ethoxycarbonyl, amino, methylamino, ethylamino, dimethylamino, diethylamino, carbamoyl, methylcarbamoyl, ethylcarbamoyl, dimethylcarbamoyl, and diethylcarbamoyl,
• ring RA represents phenylene, cycloalkylene, pyridiylene, piperidinylene, azetidinylene, pyrrolidinylene, or homopiperidinylene
• n1A represents 0 or 1,
• RB1 represents
• a hydrogen atom,
• lower alkoxy carbonylmethylene, optionally substituted with one or more substituents selected from the group consisting of a halogen, hydroxy, methoxy, ethoxy, nitro, cyano, carboxy, methoxycarbonyl, ethoxycarbonyl, amino, methylamino, ethylamino, dimethylamino, diethylamino, carbamoyl, methylcarbamoyl, ethylcarbamoyl, dimethylcarbamoyl, diethylcarbamoyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, furyl, thiophenyl, pyrrolyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, triazolyl, oxadiazolyl, tetrazolyl, pyridyl, pyridazinyl, pyrimidinyl, and pyrazinyl,
• cycloalkyloxy carbonylmethylene, optionally substituted with one or more substituents selected from the group consisting of a halogen, methyl, ethyl, hydroxy, methoxy, ethoxy, nitro, cyano, carboxy, methoxycarbonyl, ethoxycarbonyl, amino, methylamino, ethylamino, dimethylamino, diethylamino, carbamoyl, methylcarbamoyl, ethylcarbamoyl, dimethylcarbamoyl, and diethylcarbamoyl, or
• —CH2CONRB5RB6 wherein, RB5 and RB6 are the same or different and each represents a hydrogen atom, or lower alkyl or they represent a nitrogen-containing aliphatic heterocyclic group together with an adjacent nitrogen atom optionally substituted with one or more substituents selected from the group consisting of a halogen, methyl, ethyl, hydroxy, methoxy, ethoxy, nitro, cyano, carboxy, methoxycarbonyl, ethoxycarbonyl, amino, methylamino, ethylamino, dimethylamino, diethylamino, carbamoyl, methylcarbamoyl, ethylcarbamoyl, dimethylcarbamoyl, diethylcarbamoyl, hydroxymethyl, hydroxyethyl, and hydroxypropyl
• RB2 represents lower alkyl optionally substituted with one or more substituents selected from the group consisting of a halogen, hydroxy, methoxy, ethoxy, nitro, cyano, carboxy, methoxycarbonyl, ethoxycarbonyl, amino, methylamino, ethylamino, dimethylamino, diethylamino, carbamoyl, methylcarbamoyl, ethylcarbamoyl, dimethylcarbamoyl, diethylcarbamoyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, furyl, thiophenyl, pyrrolyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, triazolyl, oxadiazolyl, tetrazolyl, pyridyl, pyridazinyl, pyrimidinyl, and pyrazinyl,
• RB3 and RB4 are the same or different and each represents a halogen or lower alkyl optionally substituted with one or more substituents selected from the group consisting of a halogen, hydroxy, methoxy, ethoxy, nitro, cyano, carboxy, methoxycarbonyl, ethoxycarbonyl, amino, methylamino, ethylamino, dimethylamino, diethylamino, carbamoyl, methylcarbamoyl, ethylcarbamoyl, dimethylcarbamoyl, diethylcarbamoyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, furyl, thiophenyl, pyrrolyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, triazolyl, oxadiazolyl, tetrazolyl, pyridyl, pyridazinyl, pyrimidinyl, and pyrazinyl,
• RC1 represents a hydrogen atom, lower alkyl, or lower alkanoyl,
• RC3 represents a hydrogen atom or hydroxy,
• ring RC represents phenylene, piperidinylene, azetidinylene, pyrrolidinylene, or homopiperidinylene
• RD1 represents
• lower alkyl optionally substituted with one or more substituents selected from the group consisting of a halogen, hydroxy, methoxy, ethoxy, nitro, cyano, carboxy, methoxycarbonyl, ethoxycarbonyl, amino, methylamino, ethylamino, dimethylamino, diethylamino, carbamoyl, methylcarbamoyl, ethylcarbamoyl, dimethylcarbamoyl, diethylcarbamoyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, furyl, thiophenyl, pyrrolyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, triazolyl, oxadiazolyl, tetrazolyl, pyridyl, pyridazinyl, pyrimidinyl, and pyrazinyl, or
• lower alkoxycarbonyl optionally substituted with one or more substituents selected from the group consisting of a halogen, hydroxy, methoxy, ethoxy, nitro, cyano, carboxy, methoxycarbonyl, ethoxycarbonyl, amino, methylamino, ethylamino, dimethylamino, diethylamino, carbamoyl, methylcarbamoyl, ethylcarbamoyl, dimethylcarbamoyl, diethylcarbamoyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, furyl, thiophenyl, pyrrolyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, triazolyl, oxadiazolyl, tetrazolyl, pyridyl, pyridazinyl, pyrimidinyl, and pyrazinyl,
• RE1 and RF1 have the same definition as RA1,
• RE2 and RF2 have the same definition as RA2,
• RE3 and RF3 have the same definition as RA3,
• RE5 and RF5 have the same definition as RA5, and
• RF7 represents a hydrogen atom or a halogen);
• S represents a member selected from group consisting of
• wherein,
• the wavy line represents a bonding site to L1 or L2,
• n1a and n1b are the same or different and each represents 0 or 1,
• X1a and X1b are the same or different and each represents —C(═O)—NH—, —NH—C(═O)—, —SO2—NH—, —NH—SO2—, —O—C(═S)—NH—, —O—C(═O)—NH—, —NH—C(═O)—O—, or —NH—C(═O)—NH—except for the cases where (i) X1a is —NH—SO2—, and X1b is —SO2—NH—, (ii) n1a and n1b are 0, X1a is —C(═O)—NH—, —SO2—NH—, —O—C(═S)—NH—, —O—C(═O)—NH—, or —NH—C(═O)—NH—, and X1b is —NH—C(═O)—, —NH—SO2—, —NH—C(═O)—O—, or —NH—C(═O)—NH—, and (iii) X1a is —O—C(═S)—NH—, —O—C(═O)—NH—, —NH—C(═O)—O—, or —NH—C(═O)—NH— and X1a is —O—C(═S)—NH—, —O—C(═O)—NH—, —NH—C(═O)—O—, or —NH—C(═O)—NH—,
• R1a represents a hydrogen atom and R1b represents a hydrogen atom or lower alkyl, or R1a and R1b together represent carbonyl,
• X2a represents —C(═O)—NH—, —NH—C(═O)—, —SO2—NH—, or —NH—SO2—,
• X2b represents —C(═O)—NH—, —NH—C(═O)—, —SO2—NH—, —NH—SO2—, or —CH2-except for the case where X2a is —NH—SO2- and X2b is —SO2—NH—,
• Z2 represents CH or N except for the cases where (i) Z2 is N and X2b is —NH—C(═O)—, —SO2—NH—, or —NH—SO2— and (ii) Z2 is CH and X2b is —CH2—,
• n3a and n3b are the same or different and each represents 1 or 2,
• X3 represents —C(═O)—NH—, —NH—C(═O)—, —SO2—NH—, —NH—SO2—, —NH—C(═O)—NH—, or —NH—CH2—,
• Z3 represents CH or Nexcept for the cases where (i) Z3 is N and X3 is —NH—C(═O)—, —SO2—NH—, —NH—SO2—, —NH—C(═O)—NH—, or —NH—CH2— and (ii) Z3 is N and n3a or n3b is 1,
• X5a and X5b are the same or different and each represents —C(═O)—NH—, —NH—C(═O)—, —SO2—NH—, or —NH—SO2— except for the case where X5a is —NH—SO2— and X5b is —SO2—NH—,
• n6 represents 1 or 2,
• Ar6 represents triazolediyl, oxadiazolediyl, pyrazolediyl, thiophenediyl, or tetrahydropyridinediyl,
• X6 represents —C(═O)—NH—, —NH—C(═O)—, —SO2—NH—, —NH—SO2—, —CH2—NH— or —NH—C(═O)—NH— except for the cases where (i) Ar6 is oxadiazolediyl, pyrazolediyl, thiophenediyl, or tetrahydropyridinediyl and X6 is —NH—SO2— and (ii) n6 is 1, Ar6 is pyrazolediyl or tetrahydropyridinediyl, and X6 is —C(═O)—NH—, —SO2—NH—, —CH2—NH—, or —NH—C(═O)—NH—,
• X7 represents —C(═O)—NH—, —NH—C(═O)—, —SO2—NH—, or —NH—C(═O)—NH—,
• n7 represents 1, 2, or 3,
• Z7 represents S, SO, or SO2,
• X8a represents —C(═O)—, —CH2—, or —NH—C(═O)—,
• X8b represents a bond, —C(═O)—, —CH2—, or —CH(OH)—,
• Ar9 represents triazolediyl or oxazolediyl,
• Z9 represents CH2 or NH except for the cases where (i) Ar9 is triazolediyl and Z9 is NH and (ii) Ar9 is oxazolediyl and Z9 is CH2,
• Z10 represents O or NH,
• X11a represents —C(═O)—NH—, —SO2—NH—, or —NH—C(═O)—NH—,
• X11b represents —C(═O)—NH— or —C(═O)—,
• X12 represents —C(═O)—NH—, —NH—C(═O)—, —SO2—NH—, or —NH—C(═O)—NH—,
• Z12a represents CH2 or NH except for the case where X12 is —C(═O)—NH—, —SO2—NH—, or —NH—C(═O)—NH— and Z12a is NH,
• Z12b represents CH2 or 0 except for the case where Z12″ is NH and Z12b is O,
• Z12c represents a bond, CH2, or O except for the cases where (i) Z12b is 0 and Z12c is O and (ii) Z12a is NH and Z12c is CH2 or O,
• n13 represents 0, 1 or 2,
• n16 represents 1 or 2,
• Z16 represents a bond, CH2, or O,
• X16 represents —CH2—O—, —C(═O)—NH—, —NH—C(═O)—, or —NH—C(═O)—NH— except for the case where Z16 is O and X16 is —NH—C(═O)— or —NH—C(═O)—NH—,
• Ar16 represents triazolediyl, oxadiazolediyl or pyrazolediyl except for the cases where (i) X16 is —CH, —O— and Ar16 is oxadiazolediyl or pyrazolediyl and (ii) n16 is 1, X16 is —C(═O)—NH— or —NH—C(═O)—NH—, and Ar16 is pyrazolediyl,
• n17 represents 1 or 2,
• X17 represents —C(═O)—NH—, —NH—C(═O)—, —NH—SO2—, or —NH—C(═O)—NH—, and
• n18a, n18b, and n18c are the same or different and each represents 1 or 2.