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US 11,629,150 B2Granted
Synthesis of N-(heteroaryl)-pyrrolo[3,2-d]pyrimidin-2-amines
AssigneeG1 Therapeutics, Inc.
InventorsAlexander Smith, Hannah S. White, Francis Xavier Tavares, Sergiy Krasutsky, Jian-Xie Chen, Roberta L. Dorrow, Hua Zhong
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Abstract
This invention is in the area of synthesizing pyrimidine-based compounds useful in the treatment of disorders involving abnormal cellular proliferation, including but not limited to tumors and cancers.
Claims5
A compound of Formula II:
- wherein:
- represents a carbocycle of 3 to 8 carbons connected in a spiro-fashion to the lactam ring;
- R1 is selected from alkyl, aryl, haloalkyl, and arylalkyl;
- R2 is selected from hydrogen, carbamate, aryl, alkyl, allyl, and arylalkyl;
- and
- R5 is selected from hydrogen, halogen, —N(alkyl)(alkoxy), —NCH3OMe, alkoxy, aryloxy, —OCH2aryl, —OC(O)alkyl, —OC(O)aryl, and —OC(O)arylalkyl.
3 more elements
Dependencies are inferred from the claim text.