10-(di(phenyl)methyl)-4-hydroxy-8,9,9A,10-tetrahydro-7H-pyrrolo[1′,2′:4,5]pyrazino[1,2-b]pyridazine-3,5-dione derivatives and related compounds as inhibitors of the orthomyxovirus replication for treating influenza

A compound selected from:

• Example
• No.
• Structure
• Name
• 30
• (((9aR,10S)-10-((R)-(2,3- difluorophenyl)(phenyl)methyl)-3,5- dioxo-3,5,8,9,9a,10-hexahydro-7H- pyrrolo[1′,2′:4,5]pyrazino[1,2- b]pyridazin-4-yl)oxy)methyl methyl carbonate
• 31
• (9aR,10S)-10-((R)-(2,3- difluorophenyl)(phenyl)methyl)-3,5- dioxo-3,5,8,9,9a,10-hexahydro-7H- pyrrolo[1′,2′:4,5]pyrazino[1,2- b]pyridazin-4-yl isobutyrate
• 32
• (((9aR,10S)-10-((R)-(2,3- difluorophenyl)(phenyl)methyl)-3,5- dioxo-3,5,8,9,9a,10-hexahydro-7H- pyrrolo[1′,2′:4,5]pyrazino[1,2- b]pyridazin-4-yl)oxy)methyl isobutyrate
• 53
• (9aR,10S)-10-((R)-(2,3- difluorophenyl)(phenyl)methyl)-3,5- dioxo-3,5,8,9,9a,10-hexahydro-7H- pyrrolo[1′,2′:4,5]pyrazino[1,2- b]pyridazin-4-yl ethyl carbonate
• 54
• (9aR,10S)-10-((R)-(2,3- difluorophenyl)(phenyl)methyl)-3,5- dioxo-3,5,8,9,9a,10-hexahydro-7H- pyrrolo[1′,2′:4,5]pyrazino[1,2- b]pyridazin-4-yl methyl carbonate
• and pharmaceutically acceptable salts thereof.