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US 11,629,147 B2Granted
Triazolo-pyrimidine compounds and uses thereof
AssigneeDizal (Jiangsu) Pharmaceutical Co., Ltd.
InventorsQingbei Zeng, Changhe Qi, Honchung Tsui, Zhenfan Yang, Xiaolin Zhang
Life of this patent
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Abstract
The present disclosure relates to novel triazolo-pyrimidine compounds targeting adenosine receptors (especially A1 and A2, particularly A2a). The present disclosure also relates to pharmaceutical compositions comprising one or more of the compounds as an active ingredient, and use of the compounds in the treatment of adenosine receptor (AR) associated diseases, for example cancer such as NSCLC, RCC, prostate cancer, and breast cancer.
Claims24
A compound of Formula (I):
- or a pharmaceutically acceptable salt thereof,
- wherein,
- X is selected from amino, N—(C1-4 alkyl)amino, N,N—(C1-4 alkyl)2amino, C1-4 alkanoylamino,
- Ring A is selected from
- Z is selected from hydrogen, halogen, N—(C1-4 alkyl)amino, N,N—(C1-4 alkyl)2amino, 4-10 membered saturated or unsaturated carbocyclyl, or 4-10 membered saturated or unsaturated heterocyclyl, which can be optionally mono- or independently multi-substituted by R2,
- Y is —W—V, wherein W is O, S, —NH—, C1-4 alkylene, C1-4 alkylene-NH—, V is C1-4 alkoxyl, C1-4 alkyl-OH, amino, N—(C1-4-alkyl)amino, N,N—(C1-4 alkyl)2amino, C1-4 alkanoylamino, 5-6 membered saturated or unsaturated carbocyclyl, or 5-6 membered saturated or unsaturated heterocyclyl, which can be optionally mono- or independently multi-substituted by R3,
- each R1 is independently selected from halogen, hydroxyl, cyano, amino, carbamoyl, urea, carbamate, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxyl, C1-4 haloalkoxyl, C1-4 alkyl-OH, N—(C1-4 alkyl)amino, N,N—(C1-4 alkyl)2amino, N—(C1-4 alkyl)carbamoyl, N,N—(C1-4 alkyl)2carbamoyl, C1-4 alkanoylamino, or a 3-6 membered saturated carbocyclyl or heterocyclyl,
- each R2 is independently selected from halogen, hydroxyl, amino, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxyl, C1-4 haloalkoxyl, C1-4 alkyl-OH, N—(C1-4 alkyl)amino, N,N—(C1-4 alkyl)2amino, C1-4 alkanoylamino,
- each R3 is independently selected from halogen, hydroxyl, cyano, amino, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxyl, C1-4 haloalkoxyl, C1-4 alkyl-OH, N—(C1-4 alkyl)amino, N,N—(C1-4 alkyl)2amino, C1-4 alkanoylamino,
- m is 0, 1, 2, 3 or 4.
7 more elements
Dependencies are inferred from the claim text.