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US 11,629,146 B2Granted
Substituted [1,2,4]triazolo[4,3-a]pyrazines as modulators of sodium channel activity
AssigneePraxis Precision Medicines, Inc.
InventorsKiran Reddy, Gabriel Martinez Botella, Andrew Mark Griffin, Brian Edward Marron
Life of this patent
Estimating the term…
Abstract
The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including Dravet syndrome or epilepsy are also provided herein.
Claims14
A compound of Formula (VII):
- or a pharmaceutically acceptable salt thereof,
- wherein:
- R1 is hydrogen, CH3, C1-6 haloalkyl, O-phenyl, C3-8 carbocyclyl, or phenyl, wherein the CH3, C1-6 haloalkyl, O-phenyl, C3-8 carbocyclyl, or phenyl is optionally substituted with one or more substituents independently selected from the group consisting of halo, ORc, and 3-8 membered heterocyclyl;
- each R2 is independently hydrogen, halo, or C1-6 alkyl;
- R3 is halo, cyano, nitro, C1-6 alkyl, C(O)Rc, C(O)N(Rd)2, C(O)ORc, N(Rd)2, OR7, C3-8 carbocyclyl, or 3-8 membered heterocyclyl, wherein the C1-6 alkyl, C3-8 carbocyclyl, or 3-8 membered heterocyclyl is optionally substituted with one or more independently selected R5 substituents;
- R4 is cyano, nitro, C1-6 alkyl, C(O)Rc, C(O)N(Rd)2, C(O)ORc, N(Rd)2, ORc, C3-8 carbocyclyl, or 3-8 membered heterocyclyl, wherein the C1-6 alkyl, C3-8 carbocyclyl, or 3-8 membered heterocyclyl is optionally substituted with one or more independently selected R5 substituents;
- each R5 is independently halo, cyano, nitro, C1-6 alkyl, C(O)N(Rd)2, N(Rd)2, NRdC(O)Rc, ORc, S(O)2Rc, S(O)2N(Rd)2, S(O)2ORc, C3-8 carbocyclyl, or 3-8 membered heterocyclyl;
- each Rc is independently hydrogen or C1-6 alkyl, wherein each C1-6 alkyl is optionally and independently substituted with one or more independently selected R6 substituents;
- each Rd is independently hydrogen or C1-6 alky];
- each R6 is independently halo, cyano, C3-8 carbocyclyl, or 3-8 membered heterocyclyl, wherein each C3-8 carbocyclyl is optionally and independently substituted with one or more substituents independently selected from the group consisting of halo and cyano;
- R7 is C1-6 alkyl or C3-8 carbocyclyl, wherein the C1-6 alkyl or C3-8 carbocyclyl is optionally substituted with one or more independently selected R6 substituents;
- and
- m is 0, 1, or 2.
10 more elements
Dependencies are inferred from the claim text.