Crystal form of monomethanesulfonate of deuterated 3-(4,5-substituted aminopyrimidine)phenyl compound and preparation method therefor
AssigneeNanjing Chuangte Pharmaceutical Technology Co., Ltd.
InventorsYongqiang Zhu, Yang Yang, Ou Hai, Zhaogang Liu, Chao Feng
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Abstract
Disclosed in the present invention are a crystal form of monomethanesulfonate of a deuterated 3-(4,5-substituted aminopyrimidine)phenyl compound as represented by formula I, and a preparation method therefor. The crystal form is highly stable, can be used for treatment or prevention of diseases or conditions by means of epidermal growth factor receptors (EGFRs) in some mutation forms, can effectively inhibit the growth of a variety of tumor cells, and have an inhibiting effect on other proteases of EGFR and Her families, and thus can be used for preparing antitumor drugs.
Claims18
1. A crystal form A of monomethanesulfonate of a deuterated 3-(4,5-substituted aminopyrimidine)phenyl compound as represented by formula I:
- wherein in X-ray powder diffraction of the crystal form A, a 2θ diffraction angle has characteristic peaks at 15.42±0.2°, 17.86±0.2°, 20.58±0.2°, 21.58±0.2°, 23.86±0.2°, and 24.96±0.2°.
A crystal form B of monomethanesulfonate of a deuterated 3-(4,5-substituted aminopyrimidine)phenyl compound as represented by formula I:
- wherein in X-ray powder diffraction of the crystal form B, a 2θ diffraction angle has characteristic peaks at 10.38±0.2°, 14.9±0.2°, 18.1±0.2°, 22.68±0.2°, and 26.20±0.2°.
Dependencies are inferred from the claim text.