Small molecule inhibitors of Ebola and Lassa fever viruses and methods of use

A compound represented by formula (I):

• or a pharmaceutically acceptable salt, solvate, hydrate, prodrug, chemically-protected form, enantiomer or stereoisomer thereof;
• wherein, independently for each occurrence,
• A is N or CR8;
• Z is
• Rf are each independently selected from H, alkyl, and cycloalkyl
• R9 is selected from H, optionally substituted alkyl, amino, cycloalkyl, heterocyclyl, aryl, and heteroaryl;
• n is an integer selected from 0, 1 or 2;
• R51 is independently selected from deutero, halo, cyano, azido, alkyl, haloalkyl, fluoroalkyl, cycloalkyl, hydroxyl, alkoxy, haloalkoxy, carbocyclylalkoxy, heterocyclylalkoxy, aryloxy, heteroaryloxy, amino, alkylamino, carbocyclylamino, heterocyclylamino, arylamino, heteroarylamino, amido, alkenyl, alkynyl, carbocyclyl, aryl, heteroaryl, and carbocyclylalkoxy;
• E is selected from optionally substituted cycloalkyl, arylalkyl, cycloalkylalkyl, amino, alkoxy, cycloalkyloxy, and cycloalkylamino, or E is
• Y1 is selected from O, NR27, and CR28R29;
• Y2 is selected from O, NR30, and CR31R32;
• R26, R28, R29, R31, and R32 are each independently H, halo, optionally substituted alkyl or haloalkyl, or R26 and R29 combine to form a 3-, 4-, or 5-membered ring;
• R27 is selected from H and alkyl;
• R30 is selected from H,
• Rd is selected from alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl;
• R2 and R3 are independently selected from H, deutero, optionally substituted alkyl, haloalkyl, or R2 and R3, together with the carbon to which they are bound, combine to form a carbonyl;
• and
• R8 is selected from H, deutero, halo, hydroxyl, cyano, amino, alkyl, alkoxy, carboxy, alkoxycarbonyl, and aminocarbonyl;
• provided that E is not