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US 11,629,132 B2Granted
Compounds for inducing proliferation and differentiation of cells, and methods of use thereof
AssigneesThe Broad Institute, Inc., Massachusetts Institute of Technology
InventorsSangeeta Bhatia, Jing Shan, Michelle Palmer, Nathan Ross
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Abstract
The present invention provides methods of inducing proliferation of and/or differentiating cells comprising contacting cells with compounds within the methods of the invention. The present invention further provides cells obtainable by the methods of the invention.
Claims7
A method comprising
- transplanting a tissue or organ to a subject in need thereof, and administering to the subject an agent selected from the group consisting of:
- (i) N,N′-(methylenebis(4,1-phenylene))diacetamide (Compound 105), or a pharmaceutically acceptable salt thereof;
- and
- (ii) one or more cells obtained by contacting one or more primary liver cells with Compound 105 or a pharmaceutically acceptable salt thereof;
- wherein the tissue comprises liver tissue or the organ is a liver.
2 more elements
Dependencies are inferred from the claim text.