Compound and dimer complex embodiments for supramolecular sensing
AssigneeUVic Industry Partnerships Inc.
InventorsMeagan Beatty, Fraser Hof, Allison Selinger
Life of this patent
Estimating the term…
Abstract
Disclosed herein are embodiments of a compound that can be used as a supramolecular sensor for determining the presence of analytes (e.g., illicit drugs), and for identifying and/or quantifying the analytes. Also disclosed herein is a parallel synthesis method for making compound embodiments, as well as method embodiments for using the compound embodiments. Array embodiments comprising one or more compound embodiments disclosed herein also are described.
Claims16
A dimer complex, comprising:
- a first compound having a structure according to Formula I;
- and
- a second compound having a structure according to Formula I;
- wherein Formula I is
- wherein
- each A independently is selected from C(O)H;
- CH2OH;
- or —SO3R′, wherein each R′ independently is H or a counterion;
- or linker′-RingB′, wherein linker′ is aliphatic or heteroaliphatic and RingB′ is a ring system capable of producing a detectable signal;
- each E independently is selected from —SO3R′, wherein each R′ independently is H or a counterion;
- each J independently is selected from —SO3R′, wherein each R′ independently is H or a counterion;
- each of X1, X2, X3, and X4 independently is CH2, O, S, CH2OCH2, CH2SCH2, or NRb wherein each Rb independently is hydrogen, aliphatic, heteroaliphatic, or aromatic;
- each R independently is H, aliphatic, or a counterion;
- the linker group has a structure satisfying a Formula IA
- wherein each L and L′ independently is CH or N;
- M is NH;
- q is an integer selected from 1 to 3;
- and r is 0 or 1;
- the B ring comprises an N-functionalized nitrogen-containing ring system, a 2-ethyl-1H-benzo[de]isoquinoline-1,3(2H)-dione functional group, or a nitrobenzo[c][1,2,5]oxadiazole functional group;
- and
- each of n, m, and p independently is an integer selected from 1 to 3;
- and further wherein
- (i) the first compound and the second compound chemically interact to form the dimer complex and wherein the dimer complex does not emit a detectable signal or wherein the dimer complex emits a dimer detectable signal that is different from any detectable signal provided by the first compound, the second compound, or both;
- and
- (ii) the first compound has a structure that is different from the second compound.
A composition, comprising a plurality of homo- and heterodimer complexes, wherein the homo- and heterodimer complexes are formed from combining at least two compounds having structures according to Formula I, wherein the at least two compounds have different structures and wherein Formula I is
- wherein
- each A independently is selected from C(O)H;
- CH2OH;
- or —SO3R′, wherein each R′ independently is H or a counterion;
- or linker′-RingB′, wherein linker′ is aliphatic or heteroaliphatic and RingB′ is a ring system capable of producing a detectable signal;
- each E independently is selected from —SO3R′, wherein each R′ independently is H or a counterion;
- each J independently is selected from —SO3R′, wherein each R′ independently is H or a counterion;
- each of X1, X2, X3, and X4 independently is CH2, O, S, CH2OCH2, CH2SCH2, or NRb wherein each Rb independently is hydrogen, aliphatic, heteroaliphatic, or aromatic;
- each R independently is H, aliphatic, or a counterion;
- the linker group has a structure satisfying a Formula IA
- wherein each L and L′ independently is CH or N;
- M is NH;
- q is an integer selected from 1 to 3;
- and r is 0 or 1;
- the B ring comprises an N-functionalized nitrogen-containing ring system, a 2-ethyl-1H-benzo[de]isoquinoline-1,3(2H)-dione functional group, or a nitrobenzo[c][1,2,5]oxadiazole functional group;
- and
- each of n, m, and p independently is an integer selected from 1 to 3.
Dependencies are inferred from the claim text.