Selenopsammaplin A and derivative thereof, preparation method therefor, and composition for preventing and treating cancer, containing same as active ingredients

A method for preparing a compound of represented by the following Chemical Formula 1, the method comprising:

• synthesizing a compound represented by the following Chemical Formula 4 by adding 2,2′-diselanediyldiethanamine to a compound represented by the following Chemical Formula 3;
• and
• synthesizing the compound of represented by the following Chemical Formula 1 by subjecting the compound represented by Chemical Formula 4 to a hydrolysis reaction:
• in Chemical Formula 1, Chemical Formula 3, and Chemical Formula 4,
• X is hydrogen, a C1-5 alkyl,
• 1-naphthyl, 2-naphthyl, or 9-anthracenyl, wherein R1 to R5 are each independently hydrogen, nitro, a halogen, cyano, hydroxy, dimethylamino, methylsulfonylamide, trifluoromethyl, a C1-5 alkyl, a C1-3 alkoxy, vinyl, aryl, phenoxy, or benzoxy;
• when R3 and R4 are linked to form a ring, the resulting structure is
• and when one of R1 to R5 is phenoxy or benzoxy, a substituent of the aromatic ring thereof is a C1-3 alkyl, a C1-3 alkoxy, a halogen, trifluoromethyl, or t-butyl.

A method for preparing a compound represented by the following Chemical Formula 2, the method comprising:

• synthesizing the compound represented by the following Chemical Formula 2 by adding dithiothreitol to a compound represented by the following Chemical Formula 1:
• in Chemical Formulae 1 and 2,
• X is hydrogen, a C1-5 alkyl,
• 1-naphthyl, 2-naphthyl, or 9-anthracenyl,
• wherein R1 to R5 are each independently hydrogen, nitro, a halogen, cyano, hydroxy, dimethylamino, methylsulfonylamide, trifluoromethyl, a C1-5 alkyl, a C1-3 alkoxy, vinyl, aryl, phenoxy, or benzoxy;
• when R3 and R4 are linked to form a ring, the resulting structure is
• and
• when one of R1 to R5 is phenoxy or benzoxy, a substituent of the aromatic ring thereof is a C1-3 alkyl, a C1-3 alkoxy, a halogen, trifluoromethyl, or t-butyl.

A method for treating lung cancer or colorectal cancer, the method comprising:

• administering a compound represented by the following Chemical Formula 1 or 2, an isomer thereof, or a pharmaceutically acceptable salt thereof as an active ingredient to a subject in need thereof:
• in Chemical Formulae 1 and 2,
• X is hydrogen, a C1-5 alkyl,
• 1-naphthyl, 2-naphthyl, or 9-anthracenyl, wherein
• R1 to R5 are each independently hydrogen, nitro, a halogen, cyano, hydroxy, dimethylamino, methylsulfonylamide, trifluoromethyl, a C1-5 alkyl, a C1-3 alkoxy, vinyl, aryl, phenoxy, or benzoxy;
• when R3 and R4 are linked to form a ring, the resulting structure is
• and when one of R1 to R5 is phenoxy or benzoxy, a substituent of the aromatic ring thereof is a C1-3 alkyl, a C1-3 alkoxy, a halogen, trifluoromethyl, or t-butyl.