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US 11,629,118 B2Granted
Formulations with improved stability
AssigneeInspirna, Inc.
InventorsEduardo Martinez, Peter Rix, Eric Gruff
Life of this patent
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Abstract
Formulations containing pharmaceutically active compounds with improved stability.
Claims20
A formulation comprising:
- a compound having a structure:
- or a pharmaceutically acceptable salt thereof;
- and
- a lipophilic vehicle comprising at least one lipid excipient and at least one surfactant,
- wherein the compound, or the pharmaceutically acceptable salt thereof, is soluble in the lipophilic vehicle,
- wherein the lipophilic vehicle comprises at least two selected from the group consisting of PEG-200, PEG-300, PEG-400, a PEG castor oil, a lauroyl PEG glyceride, a stearoyl PEG glyceride, an oleoyl PEG glyceride, a caprylocapryl PEG glyceride, a PEG-20 glyceryl stearate, a glycerol oleate, a glycerol linoleate, a glycerol stearate, propylene glycol monocaprylate, polyglyceryl-3 dioleate, diethylene glycol monoethyl ether, d-alpha-tocopheryl polyethylene glycol 1000 succinate, polyoxyethylene (20) sorbitan monooleate, and polyoxyethylene (20) sorbitan monolaurate, and
- wherein the formulation is suitable for oral administration.
4 more elements
Dependencies are inferred from the claim text.