Charged isoporous materials for electrostatic separations
AssigneeTeraPore Technologies, Inc.
InventorsRachel Mika Dorin, Spencer William Robbins
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Abstract
Multiblock polymer materials, methods of preparing, and using to separate proteins, nucleic acids, other biological or other biomolecules, compounds, or solutes, with high fluxes through electrostatic interactions where the self-assembled block polymer materials contain at least one of macro, meso, or micro pores, and at least some of the pores are isoporous, and at least one polymer block contains stationary electrostatic charge, or reactive functional groups to provide large surface areas that are charged in isoporous structure.
Claims22
A charged, self-assembled poly(isoprene-b-styrene-b-4-vinyl pyridine) triblock copolymer material for solute separations, the material comprising:
- a surface layer comprising a plurality of mesopores having a size of from 5 nm to 100 nm, wherein the mesopores are isoporous and have a pore size distribution from 1 to 3, wherein the pore size distribution is defined as the ratio of the maximum pore diameter to the minimum pore diameter;
- wherein at least a portion of the 4-vinyl pyridine block is quaternized to provide the material with a positive stationary charge wherein the degree of charge on the at least a portion of the 4-vinyl pyridine block is ≤90% of all available units;
- and
- wherein the material exhibits a hydraulic permeability of 50 to 200 L·m−2·hr−1·bar−1 at a pH of 7.0.
A self-assembled, charged, A-B-C triblock copolymer material having a surface layer comprising a plurality of mesopores having a size of from 5 nm to 200 nm, wherein the mesopores are isoporous and have a pore size distribution from 1 to 3, wherein the pore size distribution is defined as the ratio of the maximum pore diameter to the minimum pore diameter are isoporous, wherein
- one polymer block of the triblock copolymer has a Tg of ≤25° C.;
- and
- one polymer block of the triblock copolymer comprises an aromatic heterocycle that is quaternized to provide the material with a positive stationary charge, the aromatic heterocycle selected from the group consisting of pyridines, pyrazines, pyrimidines, pyridazines, quinolones, isoquinolines, quinoxalines, quinazolines, penazines, isoazoles, isothiazoles, imidazoles, benzimidazoles, triazoles, and tetrazoles;
- wherein the degree of charge on the one polymer block of the triblock copolymer that is quaternized is ≤90% of all available units.
Dependencies are inferred from the claim text.