Method for reducing an amount of subvisible particles in a pharmaceutical composition

A method for reducing an amount of subvisible particles in a pharmaceutical composition contained in a medical injection device comprising a container including a barrel lubricated with a lubricant coating in contact with the pharmaceutical composition, a stopper in sliding engagement within the barrel, and a tip comprising an implantation channel, the container comprising a region extending distally from the distal end of the barrel which is not accessible to the stopper, wherein the region extending distally from the distal end of the barrel comprises the implantation channel and a dead space surrounded by a tapered wall which is not accessible by the stopper,

• the method comprising, during formation of said lubricant coating on the inner wall of the barrel, limiting lubricant from being deposited into said region extending distally from the distal end of the barrel, wherein no lubricant is applied to said region extending distally from the distal end of the barrel, and
• wherein the container further comprises a hollow needle inserted in said implantation channel, the method comprising limiting lubricant from being deposited into said implantation channel and an inner space of the hollow needle.