Non-polymeric tacrolimus drug-eluting stent and manufacturing method therefor

A manufacturing method of a tacrolimus drug-eluting stent, the method comprising:

• a) forming a nitrogen-doped titanium oxide layer on a stent surface,
• b) irradiating the titanium oxide layer with a femtosecond pulse laser to perform femtosecond laser processing, and
• c) electrospinning an electrospinning mixed solution including a tacrolimus drug and a solvent on the femtosecond laser-processed titanium oxide layer,
• wherein in b), the femtosecond laser-processed titanium oxide layer satisfies the following Relation 1:
• θF/θ0≥5 [Relation 1]
• wherein θF is a water contact angle to the femtosecond laser-processed titanium oxide layer and θ0 is a water contact angle to the femtosecond laser-unprocessed titanium oxide layer.