Collagen compositions and uses for biomaterial implants

A composition for tissue repair or wound healing comprising:

• Type I human atelocollagen and Type III human atelocollagen in an amount effective to promote wound healing at a site of surgery, injury, or wound relative to an untreated control;
• wherein the total collagen present in the composition comprises about 50% Type I human atelocollagen and about 50% Type III human atelocollagen;
• wherein the Type I human atelocollagen and the Type III human atelocollagen are derived from a source of collagen comprising insoluble amnion from human placenta, soluble amnion from human placenta, and soluble chorion from human placenta, or a combination thereof;
• wherein the Type I human atelocollagen and Type III human atelocollagen are extracted through proteolytic digestion by treating the source of collagen with pepsin, such that the source of collagen undergoes fission at one or more intermolecular crosslinks and becomes soluble in dilute acids;
• and
• wherein the proteolytic digestion digests one or more telopeptide groups on the source of collagen, thereby leaving the Type I human atelocollagen and the Type III human atelocollagen with no telopeptide terminal ends.