Use of thermolysin to reduce or eliminate bacterial biofilms from surfaces
AssigneeSmith & Nephew, Inc.
InventorsLei Shi, Catherine Van Der Kar, Aleksa Jovanovic, Eric Roche
Life of this patent
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Abstract
Methods are disclosed for the reduction or elimination of bacterial biofilms on biological and non-biological surfaces, as well as methods for the treatment of wounds, skin lesions, mucous membrane lesions, and other biological surfaces infected or contaminated with bacterial biofilms using compositions comprising thermolysin.
Claims15
A method of treating a wound, mucous membrane lesion, or skin lesion infected or contaminated with a bacterial biofilm, the method comprising topically administering to the wound, mucous membrane lesion, or skin lesion a composition consisting essentially of thermolysin and a pharmaceutically acceptable carrier, wherein the bacterial biofilm is reduced or eliminated, and wherein the wound, mucous membrane lesion, or skin lesion does not include necrotic tissue and is not in need of debridement, wherein thermolysin is the only active ingredient in the composition that reduces or eliminates the biofilm.
A method of reducing or eliminating a bacterial biofilm on a biological surface, the method comprising administering to the biological surface a composition consisting essentially of thermolysin and a pharmaceutically acceptable carrier, wherein the biological surface does not include necrotic tissue and is not in need of debridement, wherein the thermolysin is the only active ingredient in the composition that reduces or eliminates the biofilm.
A method of treating a wound, mucous membrane lesion, or skin lesion infected or contaminated with a bacterial biofilm, the method comprising topically administering to the wound, mucous membrane lesion, or skin lesion a composition consisting of thermolysin and a pharmaceutically acceptable carrier, wherein the bacterial biofilm is reduced or eliminated, and wherein the wound, mucous membrane lesion, or skin lesion does not include necrotic tissue and is not in need of debridement, wherein thermolysin is the only active ingredient in the composition that reduces or eliminates the biofilm.
A method of reducing or eliminating a bacterial biofilm on a biological surface, the method comprising administering to the biological surface a composition consisting of thermolysin and a pharmaceutically acceptable carrier, wherein the biological surface does not include necrotic tissue and is not in need of debridement, wherein the thermolysin is the only active ingredient in the composition that reduces or eliminates the biofilm.
Dependencies are inferred from the claim text.