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US 11,628,205 B2Granted
Conjugates of a factor VIII moiety having an oxime-containing linkage
AssigneeNektar Therapeutics
InventorsMary J. Bossard, Dawei Sheng
Life of this patent
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Abstract
The present disclosure provides conjugates comprising a Factor VIII moiety covalently attached via an oxime-containing linkage to a water-soluble polymer, such as for example, a polyethylene glycol polymer. Methods for preparing and for administering such conjugates, are also provided, as are water-soluble polymer oxyamine reagents useful for preparing the subject conjugates, among other things.
Claims8
A conjugate comprising a branched poly(ethylene glycol) polymer covalently attached via an oxime-containing linkage to a carbohydrate of a Factor VIII moiety, the conjugate having a structure selected from:
- where (m′) or (n) for each of the branched structures above independently ranges from about 1 to about 4,000, X is a spacer comprising a chain of atoms and having an atom chain length of from 5 to 25 atoms, where at least one of the atoms is a heteroatom selected from 0, S, and NH, and FVIII is a glycosylated Factor VIII moiety comprising carbohydrate groups, where ˜CH-FVIII is a residue of a carbonyl group of an oxidized carbohydrate on the Factor VIII moiety.
Dependencies are inferred from the claim text.