Glycopeptide compositions
AssigneeXellia Pharmaceuticals Aps
InventorsIvona Jasprica, Sabina Keser, Katarina Pindric
Life of this patent
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Abstract
Solutions comprising a glycopeptide antibiotic, for example Vancomycin, and an amino acid or amino acid derivative such as N-acetyl-Glycine or N-acetyl-D-Alanine are provided. These solutions are stable or stabilized for long-term periods at conditions of normal use and storage, and can be formulated as pharmaceutical solutions for use in subjects. Methods of manufacturing and using these solutions are also provided, as are methods of stabilizing a glycopeptide antibiotic, for example Vancomycin, using amino acids or amino acid derivatives such as N-acetyl-Glycine or N-acetyl-D-Alanine.
Claims18
A stable aqueous pharmaceutical composition comprising about 0.5% w/v vancomycin, lysine, N-acetyl-D-Alanine, and optionally polyethylene glycol, wherein
- a. the molar ratio of vancomycin to lysine is about 1:20,
- b. the molar ratio of vancomycin to N-acetyl-D-Alanine is from about 1:10 to 1:30,
- c. the amount of optional polyethylene glycol is 0.0% v/v to 1.8% v/v, and/or
- d. has a pH of from about 4 to 5.53.
Dependencies are inferred from the claim text.