Methods for prevention and treatment of acute renal injury
AssigneeCornell University
InventorsHazel H. Szeto, Diane Felsen
Life of this patent
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Abstract
The disclosure relates to a method for protecting a kidney from renal injury. For example, acute renal injury may be associated with decreased or blocked blood flow in the subject's kidney or exposure to a nephrotoxic agent, such as a radiocontrast dye. The methods include administering to the subject an effective amount of an aromatic-cationic peptide to a subject in need thereof.
Claims18
A method for protecting a kidney from acute renal injury in a subject in need thereof, the method comprising administering to the subject an effective amount of a peptide selected from the group consisting of Phe-D-Arg-Phe-Lys-NH2 (SS-20) and D-Arg-2′6′Dmt-Lys-Phe-NH2 (SS-31).
A method for treating renal injury in a subject in need thereof, the method comprising administering to the subject an effective amount of a peptide selected from the group consisting of Phe-D-Arg-Phe-Lys-NH2 (SS-20) and D-Arg-2′6′Dmt-Lys-Phe-NH2 (SS-31).
A method for protecting a kidney from chronic renal injury in a subject in need thereof, the method comprising administering to the subject an effective amount of a peptide selected from the group consisting of Phe-D-Arg-Phe-Lys-NH2 (SS-20) and D-Arg-2′6′Dmt-Lys-Phe-NH2 (SS-31), wherein the chronic renal injury is associated with administration of or exposure to a nephrotoxic agent.
Dependencies are inferred from the claim text.