Spalax fibroblast-derived anti-cancer agents

A pharmaceutical composition comprising:

• a conditioned cell culture medium harvested from a culture of primary skin and lung fibroblast cells isolated from Spalax or naked mole rat Heterocephalus, wherein the culture of fibroblast cells exhibits healthy propagation or absence of fibroblast cell senescence and the conditioned cell culture medium exhibits cancer-suppressing ability,
• at least one chemotherapeutic agent, and
• a pharmaceutically active carrier, excipient or diluent.