Methods for treating overweight or obesity
AssigneeGelesis LLC
InventorsHassan Heshmati, Eyal S. Ron, Alessandro Sannino, Yishai Zohar
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Abstract
The present invention relates to methods of managing weight, and treating overweight or obesity and treating or preventing diabetes in a subject in need thereof. In one embodiment, the method comprises the steps of (a) orally administering to the subject from about 0.7 g to about 4 g of crosslinked carboxymethylcellulose; and (b) orally administering to the subject at least about 100 mL of water per gram of crosslinked carboxymethylcellulose. Steps (a) and (b) are conducted prior to or with at least one meal per day.
Claims17
A method for treating overweight or obesity in a subject in need thereof, comprising the steps of:
- (a) orally administering to the subject from about 2.0 g to about 2.5 g of carboxymethylcellulose crosslinked with citric acid;
- (b) orally administering to the subject at least 200 mL water per gram of the crosslinked carboxymethylcellulose;
- wherein said steps (a) and (b) are conducted from 0 to 50 minutes prior to a meal;
- and
- the crosslinked carboxymethylcellulose has a tapped density of at least about 0.6 g/mL;
- an elastic modulus of at least about 350 Pa, and a media uptake ratio of at least about 50 in a 1:8 mixture of simulated gastric fluid and water.
Dependencies are inferred from the claim text.