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US 11,628,182 B2Granted
Prodrugs of deoxynucleosides for treatment of diseases cased by unbalanced nucleotide pools
AssigneeZogenix Mds, Inc.
InventorDaniel DiPietro
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Abstract
Deoxynucleotide prodrugs for treatment of diseases characterized by unbalanced nucleotide pools are provided herein.
Claims12
A method for treating a disease or disorder characterized by unbalanced nucleotide pools in a subject in need thereof comprising administering to the subject a therapeutically effective amount of at least one prodrug of Formula III:
- wherein Base refers to an optionally substituted heterocyclic base or an optionally substituted heterocyclic base with a protected amino group;
- R1 and R2 are independent selected from hydrogen;
- straight chained, branched, or cyclic alkyl;
- acyl;
- CO-alkyl;
- CO-alkoxyalkyl;
- CO-aryloxyalkyl;
- CO-substituted aryl;
- sulfonate ester;
- alkylsulfonyl;
- arylsulfonyl;
- aralkylsulfonyl;
- a lipid;
- a phospholipid;
- an amino acid;
- a carbohydrate;
- a peptide;
- and cholesterol;
- wherein at least one of R1 and R2 is not hydrogen.
16 more elements
Dependencies are inferred from the claim text.