Compounds for treating and preventing extracellular histone mediated pathologies

A method of treating an extracellular histone mediated ailment in a subject in need thereof, the method comprising:

• administering to the subject in need thereof a therapeutically effective amount of a polyanionic sulfated cellobioside compound having the general structure of:
• wherein:
• R1 is O— or S—(C1-6)alkyl or R1 is a methoxy or ethoxy group;
• and R2 to R8 are each selected from an unmodified hydroxyl group, or a sulfate group selected from O-sulfate or N-sulfate, or a pharmaceutically acceptable salt thereof,
• wherein the subject in need thereof has the extracellular histone mediated ailment,
• wherein the extracellular histone mediated ailment is caused by and/or mediated by and/or involves and/or associated with a release of extracellular histones in the subject, and
• wherein the therapeutically effective amount is sufficient to reduce, minimize or inhibit extracellular histones that (i) are cytotoxic towards the endothelium in a subject, or (ii) contribute to endothelial dysfunction in a subject, or (iii) initiate coagulation by activating platelets in a subject, or (iv) induce red cell fragility and resultant anaemia in a subject or (v) induce microthrombii forming in a subject, or (vi) induce dysfunction of the circulatory system in a subject, or (vii) induce organ dysfunction in a subject.