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US 11,628,177 B2Granted
Compositions and methods for deep dermal drug delivery
AssigneeArcutis Biotherapeutics, Inc.
InventorsDavid W. Osborne, Babak N. Tofig
Life of this patent
Estimating the term…
Abstract
Pharmaceutical compositions for the topical administration of a drug to the pilosebaceous unit and methods for administering the same. As disclosed herein, the inventors of the present invention have made the surprising discovery that pharmaceutical compositions comprising small particles of an active pharmaceutical ingredient can be administered to the pilosebaceous unit. The pharmaceutical composition can comprise SHR0302 or spironolactone as an active pharmaceutical ingredient.
Claims16
A pharmaceutical composition comprising:
- a therapeutically effective amount of spironolactone or a pharmaceutically acceptable salt thereof, wherein a primary particle size distribution of the spironolactone is characterized by a D90 value of less than about 6 μm;
- and
- a silicone selected from the group consisting of dimethicone and cyclomethicone.
A method of treating acne in a subject in need thereof comprising:
- topically administering to the subject a pharmaceutical composition comprising:
- (a) a therapeutically effective amount of spironolactone or a pharmaceutically acceptable salt thereof, wherein a primary particle size distribution of the spironolactone is characterized by a D90 value of less than about 6 μm;
- and (b) a silicone selected from the group consisting of dimethicone and cyclomethicone.
Dependencies are inferred from the claim text.