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US 11,628,176 B2Granted
Combinational drug therapies
AssigneeOpna Bio SA
InventorsBen Powell, Athanasios Tsiatis, Jackie Walling
Life of this patent
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Abstract
Disclosed is a method of treating a subject suffering from a cancer, comprising administering to the subject a combination of agents comprising: (a) Compound I: or a pharmaceutically acceptable salt thereof; and (b) one or more inhibitors of the androgen receptor signaling pathway; or (c) one or more PARP inhibitors; wherein the amount of the combination of agents is therapeutically effective in the treatment.
Claims25
A method of treating a subject suffering from a cancer, comprising administering to the subject a synergistic combination of agents comprising:
- (a) Compound I:
- or a pharmaceutically acceptable salt thereof;
- and
- (b) one or more inhibitors of the androgen receptor signaling pathway;
- or
- (c) one or more PARP inhibitors;
- wherein the combination of agents is administered in an amount that is therapeutically effective in the treatment;
- wherein the cancer is metastatic castration resistant prostate cancer, and wherein the treatment is initiated after the subject with metastatic castration resistant prostate cancer develops disease progression while currently receiving treatment with abiraterone acetate and prednisone or prednisolone.
5 more elements
Dependencies are inferred from the claim text.