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US 11,628,170 B2Granted
Treating extrapyramtdal syndrome using trapidil
AssigneeSinopia Biosciences, Inc.
InventorAarash Bordbar
Life of this patent
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Abstract
Disclosed herein are methods, pharmaceutical combinations, or kits for the prevention or treatment of extrapyramidal syndromes, for example, dyskinesia, dystonia, akathisia, or drug-induced Parkinsonism, with the administration of a therapeutic effective amount of Trapidil, a derivative, a metabolite, a prodrug, an analog, or a pharmaceutically acceptable salt thereof.
Claims23
A combination therapy method for treating Parkinson's disease in a subject in need thereof, comprising administering to the subject a combination of:
- Trapidil, a derivative, a metabolite, or a pharmaceutically acceptable salt thereof;
- and levodopa;
- thereby treating Parkinson's disease in the subject;
- wherein the derivative of Trapidil is
- or 5-piperidino-7-(N-(n-amyl)-N-(beta-hydroxyethyl)-amino)-s-triazolo(1,5-a)pyrimidine)
- wherein the metabolite of Trapidil is TP-1
- and wherein the Trapidil is administered in a dose of about 50 mg to about 300 mg.
4 more elements
Dependencies are inferred from the claim text.