CCL5 inhibitors

A compound according to Formula 1 or a tautomer thereof

• wherein:
• n is 0;
• p is 1;
• R1 and R2 are independently selected from H, OH, dichloroalkyl, trichloroalkyl, diidioalkyl, triidioalkyl, difluoroalkyl, C1-C8 straight or branched chain alkyl, C1-C8 cycloalkyl, heterocycloalkyl, alkylheterocycloalkyl, optionally substituted C1-C8 alkenyl, optionally substituted C1-C8 alkynyl, optionally substituted aryl, optionally substituted alkylaryl, optionally substituted heteroaryl, optionally substituted alkylheteroaryl, O-alkyl, O-cycloalkyl, O-alkylcycloalkyl, O-aryl, O-optionally substituted aryl, alkyl-O-aryl, alkyl-O-optionally substituted aryl, C(O)-aryl, C(O)-optionally substituted aryl, CH2C(O)-aryl, CH2C(O)-optionally substituted aryl, O-(halogen)alkyl;
• R3, if present, is selected from C1-C2 straight or branched chain alkyl, C1-C8 cycloalkyl, heterocycloalkyl, alkylheterocycloalkyl, optionally substituted C1-C2 alkenyl, optionally substituted C1-C2 alkynyl, optionally substituted aryl, optionally substituted alkylaryl, optionally substituted heteroaryl, or optionally substituted alkylheteroaryl;
• R4, R5, R6, R7, and R8, if present, are independently selected from H, C1-C8 straight or branched chain alkyl, C1-C8 cycloalkyl, heterocycloalkyl, alkylheterocycloalkyl, optionally substituted C1-C8 alkenyl, optionally substituted C1-C8 alkynyl, optionally substituted aryl, optionally substituted alkylaryl, optionally substituted heteroaryl, or optionally substituted alkylheteroaryl, and/or adjacent substituents R1 and R2, R3 and R4, R5 and R6, R7 and R8, if present, may form a saturated or unsaturated 3-7 membered carbocyclic or heterocyclic ring;
• R9 is selected from B(OH)2, B(OR10)(OR11);
• R10 and R11, if present, are independently selected from optionally substituted alkyl, cycloalkyl, alkylcycloalkyl, and/or when R10 and R11 are present and adjacent to each other can together from an alkyl bridged 5 or 6 membered heterocyclic ring, or a pharmaceutically acceptable salt, ester or prodrug form thereof.