Silicone foam compositions rapidly cross-linkable at ambient temperatures and methods of making and using same
AssigneeEthicon, Inc.
InventorsDuan Li Ou, Leo B. Kriksunov
Life of this patent
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Abstract
Provided are rapidly cross-linkable silicone foam compositions, kits, and methods for filling implanted medical devices in situ or in vivo, the implanted medical devices, including for example, body implants and tissue expanders, the compositions including a platinum divinyl disiloxane complex; a low viscosity vinyl terminated polydimethylsiloxane; a low viscosity hydride terminated polydimethylsiloxane; a silicone cross-linker; and a gas and/or gas-filled microcapsules, where the rapidly cross-linkable silicone foam composition has a viscosity of ≤150 cPs for ≥1 min. post-preparation and ≤300 cPs≤5 min. post-preparation, at ambient temperature.
Claims22
A method of filling an implanted medical device, comprising:
- receiving a catalyst fluid comprising a first low viscosity vinyl terminated polydimethylsiloxane present in an amount of from about 97 wt % to about 99.5 wt % based on the weight of the catalyst fluid, and a platinum divinyl disiloxane complex;
- receiving a cross-linker suspension comprising a second low viscosity vinyl terminated polydimethylsiloxane, a low viscosity hydride terminated polydimethylsiloxane, a silicone cross-linker, and microcapsules comprising a sterile gas;
- mixing the catalyst fluid with the cross-linker suspension to produce an injectable composition having an initial viscosity of <150 cPs for at least about 1 minute after the mixing and a viscosity of ≥50,000 cPs≤24 hours after the mixing at ambient temperature;
- and
- injecting a predetermined volume of the injectable composition into the implanted medical device.
A method of filling an implanted medical device, comprising:
- receiving a catalyst fluid comprising a first low viscosity vinyl terminated polydimethylsiloxane present in an amount of from about 97 wt % to about 99.5 wt % based on the weight of the catalyst fluid, and a platinum divinyl disiloxane complex;
- receiving a cross-linker fluid comprising a second low viscosity vinyl terminated polydimethylsiloxane, a low viscosity hydride terminated polydimethylsiloxane, and a silicone cross-linker;
- mixing the catalyst fluid with the cross-linker suspension to create an injectable composition;
- bubbling a sterile gas into the injectable composition such that the injectable composition has an initial viscosity of <150 cPs for at least about 1 minute after the mixing and a viscosity of ≥50,000 cPs≤24 hours after the mixing at ambient temperature;
- and
- injecting a predetermined volume of the injectable composition into the implanted medical device.
Dependencies are inferred from the claim text.