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US 11,624,747 B2Granted
Biomarkers for the early detection of breast cancer
AssigneesArizona Board of Regents, Dana-Farber Cancer Institute, Inc., President and Fellows of Harvard College
InventorsJoshua Labaer, Karen Sue Anderson, Garrick Wallstrom, Sahar Sibani, Niroshan Ramachandran
Life of this patent
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Abstract
The present invention provides reagents and methods for breast cancer detection.
Claims6
A polypeptide probe set comprising:
- a SF3A1 (SEQ ID NO:
- 2) isolated polypeptide (or antigenic fragment thereof) and a UBAP1 (SEQ ID NO:
- 47) isolated polypeptide (or antigenic fragment thereof) and one or more additional isolated polypeptides selected from the group consisting of ATP6AP1 (SEQ ID NO:
- 13), PDCD6IP (SEQ ID NO:
- 21), DBT (SEQ ID NO:
- 25), CSNK1E (SEQ ID NO:
- 9), FRS3 (SEQ ID NO:
- 3), HOXD1 (SEQ ID NO:
- 7), C15orf48 (SEQ ID NO:
- 35), MYOZ2 (SEQ ID NO:
- 33), BAT4 (SEQ ID NO:
- 5), BMX (SEQ ID NO:
- 45), RAB5A (SEQ ID NO:
- 23), GPR157 (SEQ ID NO:
- 43), ZMYM6 (SEQ ID NO:
- 41), SLC33A1 (SEQ ID NO:
- 11), TRIM32 (SEQ ID NO:
- 37), ALG10 (SEQ ID NO:
- 27), TFCP2 (SEQ ID NO:
- 49), SERPINH1 (SEQ ID NO:
- 51), SELL (SEQ ID NO:
- 55), ZNF510 (SEQ ID NO:
- 53), or antigenic fragments of any of the above;
- wherein each of the isolated polypeptides of the polypeptide probe set comprises a detectable tag;
- wherein the detectable tag is not a naturally occurring part of the isolated polypeptide;
- and wherein the probe set comprises no more than 100 different polypeptides.
23 more elements
Dependencies are inferred from the claim text.