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US 11,624,737 B2Granted
Methods for detecting lacosamide by mass spectrometry
AssigneeQuest Diagnostics Investments Incorporated
InventorsBeatrisa Boyadzhyan, Karin Thomassian, Anita Dermartirosian, Lou Jambor
Life of this patent
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Abstract
Provided are methods for determining the amount of lacosamide in a sample using mass spectrometry. The methods generally involve ionizing lacosamide in a sample and detecting and quantifying the amount of the ion to determine the amount of lacosamide in the sample.
Claims8
A method for determining the amount of lacosamide in a sample, said method comprising:
- (i) purifying lacosamide from said sample by high performance liquid chromatography (HPLC);
- (ii) ionizing lacosamide to produce at least two lacosamide fragment ions comprising a quantifier ion and a qualifier ion detectable by mass spectrometry;
- (iii) determining the amount of lacosamide by measuring the amount of a quantifier ion and confirming the identity of the lacosamide ion by detecting a qualifier ion by mass spectrometry.
Dependencies are inferred from the claim text.