Collagen-binding agent compositions and methods of using the same
AssigneesBoard of Trustees of the University of Arkansas, The Kitasato Institute
InventorsJoshua Sakon, Jeffrey Roeser, Ryan Bauer, Katarzyna Janowska, Keisuke Tanaka, Osamu Matsushita, Kentaro Uchida
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Abstract
The invention generally relates to collagen-binding agent compositions and methods of using the same. More specifically, the invention relates in part to new collagen-binding agent compositions and methods that may be used to treat damaged collagen within tissues or used to specifically target therapeutics to tissues containing undamaged or damaged collagen.
Claims9
A collagen-binding agent comprising a first collagen-binding domain and a second collagen-binding domain linked by a domain linker and a therapeutic agent linked to at least one of the collagen-binding domains by a therapeutic agent linker,
- wherein the collagen-binding agent lacks collagenase activity;
- wherein the therapeutic agent is fibroblast growth factor (FGF);
- wherein the two collagen-binding domains bind to collagen with a KD of between 100 μM and 0.1 nM;
- wherein the first collagen-binding domain is selected from the group consisting of the polypeptides of SEQ ID NOs:
- 1-14, and the second collagen-binding domain is selected from the group consisting of the polypeptides of SEQ ID NOs:
- 15-30;
- and
- wherein the C-terminus of the first collagen-binding domain is linked to the N-terminus of the second collagen-binding domain by the domain linker.
Dependencies are inferred from the claim text.