Bicyclic compounds for diagnosis and therapy

A compound of formula (IIa):

• and all derivatives, stereoisomers, racemic mixtures, pharmaceutically acceptable salts, hydrates, solvates, prodrugs and polymorphs thereof;
• wherein
• the compound can be optionally detectably labeled by replacing any atom at any position with a label, and wherein the label is a radionuclide, a positron emitter, or a gamma emitter;
• is selected from the group consisting of
• hydrogen and alkyl, wherein
• and alkyl can be attached at any available position, and
• wherein
• can be optionally substituted by one or more substituents RD;
• is
• wherein
• can be attached at any available position, and wherein
• can be optionally substituted by one or more substituents RE;
• or both, can be optionally substituted by a leaving group (LG) at any available position, wherein the compound is capable of being detectably labeled upon replacement of the LG with a radionuclide, a positron emitter, or a gamma emitter;
• for each occurrence, Rd is independently selected from the group consisting of halogen, —OH, —O-alkyl and hydrogen;
• for each occurrence, Re is independently selected from the group consisting of hydrogen, —(CH2CH2—O)n—Rf, —(CH2CH2—O)n—(CH2CH2)—Rd, alkyl, carbocyclyl and heterocyclyl, wherein alkyl, carbocyclyl and heterocyclyl can be optionally substituted,
• for each occurrence, Rf is independently selected from the group consisting of hydrogen, and alkyl, wherein alkyl can be optionally substituted;
• for each occurrence, RD is independently selected from the group consisting of halogen, CN, —O—R10, —NR10R11, —CONR10R11, —N(R10)—C(O)—R11, —N(R10)—C(O)—O—R11, —(O—CH2CH2)n—Rd, ═O, alkyl, carbocyclyl, carbocyclylalkyl, heterocyclyl, heterocyclylalkyl, alkenyl, and alkynyl;
• for each occurrence, RE is independently selected from the group consisting of halogen, CN, —O—R10, —NR10R11, —CONR10R11, —N(R10)—C(O)—R11, —N(R10—C(O)—O—R11, —(O—CH2CH2)n—Rd, ═O, alkyl, carbocyclyl, carbocyclylalkyl, heterocyclyl, heterocyclylalkyl, alkenyl, and alkynyl, wherein alkyl, carbocyclyl, carbocyclylalkyl, heterocyclyl, heterocyclylalkyl, alkenyl, and alkynyl can be optionally substituted, or if more than one group RE is present and two of the groups RE are adjacent, they can optionally be taken together and can form a 5- to 8-membered ring containing carbon atoms and optionally one or more heteroatoms or one or more moieties comprising one or more heteroatoms, wherein the one or more heteroatoms are selected from O, S, or N and wherein the 5- to 8-membered ring may be substituted;
• for each occurrence, R10 is independently selected from the group consisting of:
• hydrogen, alkyl, carbocyclyl, carbocyclylalkyl, heterocyclyl, and heterocyclylalkyl, wherein alkyl, carbocyclyl, carbocyclylalkyl, heterocyclyl, and heterocyclylalkyl can be optionally substituted;
• for each occurrence, R11 is independently selected from the group consisting of:
• hydrogen, alkyl, carbocyclyl, carbocyclylalkyl, heterocyclyl, and heterocyclylalkyl, wherein alkyl, carbocyclyl, carbocyclylalkyl, heterocyclyl, and heterocyclylalkyl can be optionally substituted;
• for each occurrence, n is independently 1 to 4.